blood-brain barrier tagged posts

COVID-19 Virus enters the Brain, research strongly suggests

Illustration of a storm in your brain from COVID-19

The S1 protein likely causes the brain to release inflammatory products causing a storm in the brain, researchers said. Alice Gray

A new study shows how spike protein crosses the blood-brain barrier. The SARS-CoV-2 virus, like many viruses before it, is bad news for the brain. In a new study, researchers found that the spike protein, often depicted as the red arms of the virus, can cross the blood-brain barrier in mice. The spike proteins alone can cause brain fog. Since the spike protein enters the brain, the virus also is likely to cross into the brain.

In a study published Dec.16 in Nature Neuroscience, researchers found that the spike protein, often depicted as the red arms of the virus, can cross the blood-brain barrier in mice.
This strongly suggests that SARS-CoV-2, the cause ...

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Glioblastoma Nanomedicine crosses into Brain in mice, Eradicates recurring brain Cancer

Macroscopic pathology of glioblastoma multiforme. Image credit: CC BY-SA 4.0 – Sbrandner

A new synthetic protein nanoparticle capable of slipping past the nearly impermeable blood-brain barrier in mice could deliver cancer-killing drugs directly to malignant brain tumors, new research from the University of Michigan shows. ‘I’ve worked in this field for more than 10 years and have not seen anything like this.’

The study is the first to demonstrate an intravenous medication that can cross the blood-brain barrier.

The discovery could one day enable new clinical therapies for treating glioblastoma, the most common and aggressive form of brain cancer in adults, and one whose incidence is rising in many countries...

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Bringing Drugs to the brain with Nanoparticles to treat Neurodegenerative diseases

After several years of research on effective and safe nanoparticles, the research team will continue laboratory testing, targeting the delivery of active ingredients to other animal models with ultimate clinical applications.

Researchers from the Institut national de la recherche scientifique (INRS) have shown that nanoparticles could be used to deliver drugs to the brain to treat neurodegenerative diseases.

The blood-brain barrier is the main obstacle in treating neurodegenerative diseases such as Alzheimer and Parkinson. According to a recent study conducted by Jean-Michel Rabanel, a postdoctoral researcher under the supervision of Professor Charles Ramassamy, nanoparticles with specific properties could cross this barrier and be captured by neuronal cells...

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