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    Blood Factor Can Turn Back Time in the Aging Brain

    August 17, 2023, Categories  Biology/Biotechnology, Health/Medical

    Blood factor can turn back time in the aging brain
    Systemic PF4 enhances adult hippocampal neurogenesis in vivo. a Experimental design of PF4 injection paradigm in young mice. b, c Intravenous (i.v.) PF4 injections for 1 week did not affect neural precursor cell proliferation in the subgranular zone (SGZ; n = 10 mice in saline group; n = 9 mice in PF4 group; counts of one hemisphere), but increased the number of doublecortin+ (DCX+) cells (n = 15 mice per group; counts of one hemisphere). d Experimental design of the double-labeling paradigm with CldU and IdU. e Acute administration of PF4 did not affect neural precursor cell proliferation, including the recruitment of cells from quiescence (n = 20 mice per group). f Running paradigm of PF4 knockout (KO) mice. g Representative images of Ki67+ cells in the S...
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