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    blood metabolite variation tagged posts

    The Gut Microbiome’s Supersized Role in Shaping Molecules in our Blood

    November 11, 2022, Categories  Biology/Biotechnology, Health/Medical

    Metabolites associated with both genetics and the microbiome. (A) The 20 metabolites with the highest total R² that were significantly associated with both host genetics and the microbiome. Blue and green colored bars denote individual R² values in genetics-only and microbiome-only regression models, respectively. Gray bars denote R² values from regression using joined genetics and microbiome data. 0.9% of the variance in butyrylcarnitine plasma abundance was explained by microbial features (i.e. too little to be visible in the barplot). (B) R² values obtained by either adding individual contributions of genetics and the microbiome (additive) or by performing a joint regression (joint). The difference between the two groups indicates a small, but nonetheless significant, overlap in variance explained by genetics and the microbiome. However, the variances explained by host genetics and the microbiome were largely additive. Stars denote significance (*** -p<0.001).
    Metabolites associated with both genetics and the microbiome. (A) The 20 metabolites with the highest total R² that were significantly associated with both host genetics and the microbiome. Blue and green colored bars denote individual R² values in genetics-only and microbiome-only regression models, respectively. Gray bars denote R² values from regression using joined genetics and microbiome data. 0.9% of the variance in butyrylcarnitine plasma abundance was explained by microbial features (i.e. too little to be visible in the barplot). (B) R² values obtained by either adding individual contributions of genetics and the microbiome (additive) or by performing a joint regression (joint)...
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