Loss of a key protein leads to defects in skeletal development including reduced bone density and a shortening of the fingers and toes – brachydactyly. The discovery was made by researchers at Penn State University who knocked out the Speckle-type POZ Protein (Spop) in the mouse and characterized the impact on bone development. The research redefines the role of Spop during bone development and provides a new potential target for the diagnosis and treatment of bone diseases such as osteoporosis.
“The Spop protein is involved in Hedgehog signaling – a well-studied cell-to-cell communicatio...
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