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    botulinum toxin tagged posts

    Botulism Breakthrough? Taming botulinum toxin to deliver therapeutics

    January 11, 2021, Categories  Biology/Biotechnology, Health/Medical

    botulism treatment
    The toxin-based delivery platform consists of the modified botulinum toxin at upper left (protease domain in gold, translocation domain in blue, and receptor-binding domain in purple) and the nanobody (the pink tag). When this nanobody-toxin fusion protein binds to the receptor (cyan) on the neuron surface, the cell takes it in through the process of endocytosis, corralling the fusion protein inside a vesicle (light green circle). The toxin’s protease domain, carrying the nanobody, then crosses into the interior of the cell. (Image: Sicai Zhang/Dong Lab, Boston Children’s Hospital)

    Treatment reverses paralysis in mice; offers a general delivery platform for neurologic drugs. Currently there’s no treatment for botulism once the toxin gets into neurons...

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