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    brain aging process tagged posts

    Scientists discover Genetic Timetable of Brain’s Aging Process

    September 14, 2017, Categories  Biology/Biotechnology, Health/Medical

    Trajectories and turning points characterise brain age. (a) Percentage of TTTPs at each age of human lifespan. Mean age is 26.0 years for males and 27.5 years for females. (b) Percentage of TTTPs at each age of human lifespan using three different methods for fitting splines. Mean age is 31.3 years using cubic splines with 3 degrees of freedom, 21.6 years using cubic splines with 4 degrees of freedom and 25.2 years using Loess regression. (c) Percentage of TTTPs at each age of mouse. Mean age is 156 days for males and 165 days for females. (d) Cumulative sum of TTTP scores for every year of life in the Braincloud dataset. (e) Cumulative sum of TTTP scores for every year of life in the mouse hippocampus dataset. (f) The TTTPs for genes with the greatest expression changes prior to the TTTP (ΔE) were concentrated around the late-twenties. (g) Percentage of probes associated with TTTPs that up- or down-regulate prior to turning. (h) Percentage of probes with TTTPs which plateau or reverse after turning. (i) and (j). Age of individual mice and humans can be accurately predicted using a Support Vector Machine trained on the expression data. Individual points represent each mRNA sample.

    Trajectories and turning points characterise brain age. (a) Percentage of TTTPs at each age of human lifespan. Mean age is 26.0 years for males and 27.5 years for females. (b) Percentage of TTTPs at each age of human lifespan using three different methods for fitting splines. Mean age is 31.3 years using cubic splines with 3 degrees of freedom, 21.6 years using cubic splines with 4 degrees of freedom and 25.2 years using Loess regression. (c) Percentage of TTTPs at each age of mouse. Mean age is 156 days for males and 165 days for females. (d) Cumulative sum of TTTP scores for every year of life in the Braincloud dataset. (e) Cumulative sum of TTTP scores for every year of life in the mouse hippocampus dataset...

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