brain inflammation and obesity tagged posts

A mediobasal hypothalamus (MBH) section shows microglia (green) in contact with AgRP neurons (red), which are critical hypothalamic neurons in the regulation of food intake and body weight. Credit: Image by the Suneil Koliwad Lab

Diet study finds link between brain inflammation and obesity in mice. Immune cells in the brain trigger overeating and weight gain in response to diets rich in fat, according to a new study in mice led by researchers from UC San Francisco and the University of Washington Medical Center. Brain-resident microglia could be targets for obesity treatments that might avoid many side effects of the obesity drugs currently in clinical use.

“Microglia are not neurons, but they account for 10 to 15% of the cells in the brain,” said Suneil Koliwad, MD, PhD, assistant profess...