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How the Brain tells the Liver to start Recycling after Fasting

The picture is divided into two halves and shows a colourful staining of cells under the microscope. On the right, the pink staining is much stronger.
AgRP neurons in the brain are activated by fasting. The images show immunostaining of neurons from mice that fast for four hours (right) and mice that do not fast (left). Stained are AgRP neurons (Cyan), POMC neurons (Yellow) and a marker for synaptic activity (cFOS, Magenta).
© Weiyi Chen/ Max Planck Institute for Metabolism Research

Fasting triggers autophagy in our body. The body switches on the waste disposal system in the cells and gains new energy. Researchers at the Max Planck Institute for Metabolism Research in Cologne have now shown in mice that the brain plays a decisive role in this process.

Even after a short period of fasting, the brain triggers the release of the hormone corticosterone and thus initiates autophagy in the liver...

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