α2A agonists directly affect the non-amyloidogenic pathway and are neuroprotective through sAPPα.
In trials on rats, the drug brimonidine, which is routinely used to lower eye pressure in glaucoma patients, has been found to reduce the formation of amyloid proteins in the retina, which are believed to be linked to Alzheimer’s. The research was reported in the journal Cell Death and Disease. Amyloid plaques can be seen in the retinas of people with Alzheimer’s, so the researchers say the retina can be viewed as an extension of the brain that provides an opportunity to diagnose and track progression of Alzheimer’s.
Scientists found that brimonidine reduces neurodegeneration of cells in the retina by cutting the levels of beta amyloid in the eye...
Read More
Recent Comments