Brown fat tagged posts

A hidden “backup heater” that helps burn fat and boost metabolism

Weisensee Lab

Scientists at Washington University School of Medicine in St. Louis have uncovered a new way that brown fat, a type of fat that burns energy, can boost the body’s metabolism. This process allows cells to consume more fuel and generate heat, improving overall metabolic health. Conducted in mice, the research points to new possibilities for using brown fat to address metabolic conditions such as insulin resistance and obesity.

The findings were published Sept. 17 in Nature.

Brown fat is unique because it turns energy (calories) from food into heat. Unlike white fat, which stores energy, or muscle, which uses it immediately, brown fat helps keep the body warm in cold environments...

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Pain Receptors linked to the Generation of Energy-burning Fat cells: implications for Obesity Therapy

Brown adipocytes derived from progenitors expressing the Trpv1 receptor are labeled with Green Fluorescent Protein (GFP) and are found in brown adipose tissue of mice exposed to cold temperature. ( © Joslin Diabetes Center 2021)

A new source of energy-expending brown fat cells has been uncovered by researchers at the Joslin Diabetes Center, which they say points towards potential new therapeutic options for obesity. According to the new report, published in Nature Metabolism, the key lies in the expression of a receptor called Trpv1 (temperature-sensitive ion channel transient receptor potential cation subfamily V member 1) — a protein known to sense noxious stimuli, including pain and temperature.

Specifically, the authors point to smooth muscle cells expressing the Trpv1 receptor...

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Study of 50,000 people finds Brown Fat may Protect against Many Diseases

Brown fat scan
In these PET scans, the person on the left has abundant brown fat around the neck and cervical spine. The person on the right has no detectable brown fat.
(Courtesy of Andreas G. Wibmer and Heiko Schöder)

Brown fat is that magical tissue that you would want more of. Unlike white fat, which stores calories, brown fat burns energy and scientists hope it may hold the key to new obesity treatments. But it has long been unclear whether people with ample brown fat truly enjoy better health. For one thing, it has been hard to even identify such individuals since brown fat is hidden deep inside the body.

Now, a new study in Nature Medicine offers strong evidence: among over 52,000 participants, those who had detectable brown fat were less likely than their peers to suffer cardiac and metabo...

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Brown Fat can Burn Energy in an unexpected way

FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesisNature Communications, 2020; 11 (1) DOI: 10.1038/s41467-020-15055-9

Researchers have discovered an unexpected biological pathway by which brown fat cells can translate energy into heat. When we are exposed to sufficient cold or exercise, small clusters of brown fat cells in our bodies begin to burn up energy. Since 2009, when researchers at Joslin Diabetes Center and other institutions discovered that this helpful form of fat can be active in adults, scientists have sought to turn up the heat from these cells to treat obesity, diabetes and other metabolic conditions.

Researchers in the lab of Joslin’s Yu-Hua Tseng, PhD, a Senior Investigator in the Section on Integrative Physiology and Metabolism, now have dis...

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