cancer cells tagged posts

Foundational Technology to Make Cancer Cells Revert to Normal Cells?

Schematic diagram of the research results. Professor Kwang-Hyun Cho’s research team developed a source technology to systematically discover key control factors that can induce reversibility of colon cancer cells through a systems biology approach and a digital twin simulation analysis of the differentiation trajectory of normal colon cells, and verified the effects of reversion on actual colon cancer through molecular cell experiments and animal experiments. 

A research team has developed a groundbreaking technology that can treat colon cancer by converting cancer cells into a state resembling normal colon cells without killing them, thus avoiding side effects.

Despite the development of numerous cancer treatment technologies, the common goal of current cancer therapies is to elim...

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Clogged Arteries Worsened by Cells that Behave like Cancer Cells

Columbia University researchers have found cells inside clogged arteries share similarities with cancer and aggravate atherosclerosis, raising the possibility that anticancer drugs could be used to treat atherosclerosis and prevent heart attacks.

Their study found that smooth muscle cells that normally line the inside of our arteries migrate into atherosclerotic plaques, change their cell identity, activate cancer genes, and proliferate inside the plaques.

“Our study shows that these transformed muscle cells are driving atherosclerosis, opening the door to new ways to treat the disease, potentially with existing cancer drugs,” says Muredach Reilly, MD, the Florence and Herbert Irving Endowed Professor of Medicine at Columbia University Vagelos College of Physicians and Surgeons ...

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‘Trojan horse’ approach to kill Cancer Cells Without using Drugs

Nano-pPAAM.jpg
Image: The anti-cancer therapeutic nanoparticle is ultrasmall, with a diameter of 30 nanometres, or approximately 30,000 times smaller than a strand of human hair, and is named Nano-pPAAM.

Cancer cells are killed in lab experiments and tumour growth reduced in mice, using a new approach that turns a nanoparticle into a ‘Trojan horse’ that causes cancer cells to self-destruct, a research team at the Nanyang Technological University, Singapore (NTU Singapore) has found.

The researchers created their ‘Trojan horse’ nanoparticle by coating it with a specific amino acid — L-phenylalanine — that cancer cells rely on, along with other similar amino acids, to survive and grow...

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New research identifies gene that Hides Cancer cells from Immunotherapy

Highlights

•The early embryonic transcription factor DUX4 is active in many human cancers
•DUX4-expressing cancers are characterized by low anti-tumor immune activity
•DUX4 blocks interferon-γ-mediated induction of MHC class I and antigen presentation
•DUX4 is significantly associated with failure to respond to anti-CTLA-4 therapy

A team at Fred Hutchinson Cancer Research Center has identified a gene that could make immunotherapy treatments, specifically checkpoint inhibitors, work for a wider variety of cancer patients. The study, published today in Developmental Cell, found that when the DUX4 gene is expressed in cancer cells, it can prevent the cancer from being recognized and destroyed by the immune system.

The team, led by Drs...

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