cancer-fighting tagged posts

An Omega-3 that’s Poison for Tumors

UCLouvain researchers used a 3D tumour cell culture system, called spheroidsIn the presence of DHA, spheroids first grow and then implode

3D tumors that disintegrate within a few days thanks to the action of a well-known omega-3 (DHA, found mainly in fish) – this is a promising discovery. Hungry for fatty acids, tumor cells in acidosis gorge themselves on DHA but are unable to store it correctly and literally poison themselves. The result? They die.

So-called “good fatty acids” are essential for human health and much sought after by those who try to eat healthily. Among the Omega-3 fatty acids, DHA or docosahexaenoic acid is crucial to brain function, vision and the regulation of inflammatory phenomena.

In addition to these virtues, DHA is also associated with a reduction in ...

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Cancer-fighting Gene Restrains ‘Jumping Genes’

Retrotransposons are “handcuffed” by the tumor suppressor gene
This illustration depicts how retrotransposons are “handcuffed” by the tumor suppressor gene p53. But when p53 is lost, these mobile elements can erupt. Credit: Study authors Amanda Jones and Bhavana Tiwari. Artwork by Angela Diehl.

Finding sheds light on why mutations of the gene p53 are associated with cancer and could lead to new diagnostics or treatments
About half of all tumors have mutations of the gene p53, normally responsible for warding off cancer. Now, UT Southwestern scientists have discovered a new role for p53 in its fight against tumors: preventing retrotransposons, or “jumping genes,” from hopping around the human genome. In cells with missing or mutated p53, the team found, retrotransposons move and multiply more than usual...

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Red Onions pack a Cancer-fighting punch, study reveals

Abdulmonem I. Murayyan, Cynthya M. Manohar, Gordon Hayward, Suresh Neethirajan. Antiproliferative activity of Ontario grown onions against colorectal adenocarcinoma cells. Food Research International, 2017; 96: 12 DOI: 10.1016/j.foodres.2017.03.017

Abdulmonem I. Murayyan, Cynthya M. Manohar, Gordon Hayward, Suresh Neethirajan. Antiproliferative activity of Ontario grown onions against colorectal adenocarcinoma cells. Food Research International, 2017; 96: 12 DOI: 10.1016/j.foodres.2017.03.017

Not all onions are created equal. Engineering professor Suresh Neethirajan and PhD student Abdulmonem Murayyan tested 5 onion types grown in Ontario and discovered the Ruby Ring onion variety came out on top. Onions as a superfood are still not well known. But they contain one of the highest concentrations of quercetin, a type of flavonoid, and Ontario onions boasts particularly high levels of the compound compared to some parts of the world.

The Guelph study revealed that the red onion not only has high levels of quercetin, but also high amount...

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