Cancer immunotherapy tagged posts

Good-Guy Bacteria may help Cancer Immunotherapies do their job

Rick Spurr, surrounded by some of his grandchildren, was diagnosed with metastatic melanoma, which was discovered on his lungs while he was fighting off a bout of pneumonia. Credit: UT Southwestern

Rick Spurr, surrounded by some of his grandchildren, was diagnosed with metastatic melanoma, which was discovered on his lungs while he was fighting off a bout of pneumonia. Credit: UT Southwestern

Individuals with certain types of bacteria in their gut may be more likely to respond well to cancer immunotherapy, researchers at the Harold C. Simmons Comprehensive Cancer Center found in a study of patients with metastatic melanoma. The incidence of melanoma has been increasing over the past 40 years. Immunotherapies have dramatically improved the outlook for patients with metastatic melanoma in the past half-dozen years, but still only about half of these patients go into remission.

UT Southwestern cancer researchers analyzed the gut bacteria of 39 melanoma patients who were treated with imm...

Read More

A novel DNA Vaccine design improves chances of inducing Anti-Tumor Immunity

Anti-tumor Immunity Elicited by pSynConWT1-S(A) Mice were challenged with 106 ...

Anti-tumor Immunity Elicited by pSynConWT1-S (A) Mice were challenged with 106 mWT1-C1498 tumor cells injected subcutaneously and were vaccinated weekly starting 3 days post-tumor implant. Tumor measurements are reported in terms of tumor volume only for surviving mice until day 28. (B) Survival data from the tumor therapeutic challenge in (A). Vaccination with pSynConWT1-S extended survival in tumor-bearing mice. (C) Representative image of tumor size in naive or pSynConWT1-S vaccinated groups at day 14 post-mWT1-C1498 implantation. Error bars represent the average ± SEM.

Scientists at The Wistar Institute and Inovio Pharmaceuticals, Inc...

Read More