cancer treatment tagged posts

Scientists develop new CRISPR Gene Editing Platform for Precision Medicine and Cancer Treatment

Scientists develop new CRISPR gene editing platform for precision medicine and cancer treatment
Graphical abstract. Credit: Theranostics (2024). DOI: 10.7150/thno.92133

Researchers at Columbia University College of Dental Medicine have developed an exosome-based platform, “safeEXO-Cas,” that significantly enhances the delivery of CRISPR/Cas9 genome editing components to specific cells and tissues.

CRISPR/Cas9 is a unique technology that enables geneticists and medical researchers to edit parts of the genome by removing, adding or altering sections of the DNA sequence. The study, published in Theranostics, demonstrates the potential of this innovative platform to revolutionize gene therapy and precision medicine.

The research, led by Dr...

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Bendy X-ray Detectors could Revolutionize Cancer Treatment

New materials developed at the University of Surrey could pave the way for a new generation of flexible X-ray detectors, with potential applications ranging from cancer treatment to better airport scanners.

Traditionally, X-ray detectors are made of heavy, rigid material such as silicon or germanium. New, flexible detectors are cheaper and can be shaped around the objects that need to be scanned, improving accuracy when screening patients and reducing risk when imaging tumors and administering radiotherapy.

Dr. Prabodhi Nanayakkara, who led the research at the University of Surrey, said, “This new material is flexible, low-cost, and sensitive. But what’s exciting is that this material is tissue equivalent...

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World-first discovery paves way to New Cancer Treatment

Cancer

Australian researchers have discovered a new way to target an aggressive childhood cancer, neuroblastoma, one of the most common and dangerous cancers in young children.

The discovery may also have important implications for some other aggressive cancers in children, including certain brain tumours, as well as some adult cancers, including ovarian and prostate cancer.

The new research, led by scientists at Children’s Cancer Institute and published in Nature Communications, has discovered that a cellular protein called ALYREF plays a crucial role in accelerating the effects of the cancer driver gene, MYCN, in neuroblastoma.

Scientists have known for some time that the one third of children with neuroblastoma who have very high levels of MYCN in their cancer cells have a much p...

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Scientists Decipher 3D structure of a Promising Molecular Target for Cancer Treatment

The 3D structure of human ATP-citrate lyase, a metabolic enzyme that plays a key role in cancer cell proliferation and other processes.
Credit: Nimbus Therapeutics; Liang Tong, Columbia University, Nature

Discovery could be a major step in developing therapies for cancer, controlling cholesterol. Columbia University scientists, in collaboration with researchers from Nimbus Therapeutics, have demystified a metabolic enzyme that could be the next major molecular target in cancer treatment.

The team has successfully determined the 3D structure of human ATP-citrate lyase (ACLY) – which plays a key role in cancer cell proliferation and other cellular processes – for the first time...

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