cancer treatment tagged posts

Australian researchers have discovered a new way to target an aggressive childhood cancer, neuroblastoma, one of the most common and dangerous cancers in young children.

The discovery may also have important implications for some other aggressive cancers in children, including certain brain tumours, as well as some adult cancers, including ovarian and prostate cancer.

The new research, led by scientists at Children’s Cancer Institute and published in Nature Communications, has discovered that a cellular protein called ALYREF plays a crucial role in accelerating the effects of the cancer driver gene, MYCN, in neuroblastoma.

Scientists have known for some time that the one third of children with neuroblastoma who have very high levels of MYCN in their cancer cells have a much p...

Discovery could be a major step in developing therapies for cancer, controlling cholesterol. Columbia University scientists, in collaboration with researchers from Nimbus Therapeutics, have demystified a metabolic enzyme that could be the next major molecular target in cancer treatment.

The team has successfully determined the 3D structure of human ATP-citrate lyase (ACLY) – which plays a key role in cancer cell proliferation and other cellular processes – for the first time...

Credit: Jian Yang, Yixue Su Artist’s conception of nanoparticle-carrying immune cells that target tumors and release drug-loaded nanoparticles for cancer treatment.

Penn State engineers have conjugating biodegradable polymer nanoparticles encapsulated with chosen cancer-fighting drugs into immune cells to create a smart, targeted system to attack cancers of specific types. “The traditional way to deliver drugs to tumors is to put the drug inside some type of nanoparticle and inject those particles into the bloodstream,” said Jian Yang, professor of biomedical engineering, Penn State. “Because the particles are so small, if they happen to reach the tumor site they have a chance of penetrating through the blood vessel wall because the vasculature of tumors is usually leaky.”

The odds of in...

This diagram describes how the device Dr. Hood helped to develop is implanted into a cancerous tumor. Credit: Lyle Hood/UTSA

Medicine diffusion capsule could locally treat multiple ailments and diseases over several weeks. This new device that could revolutionize the delivery of medicine. “The problem with most drug-delivery systems is that you have a specific minimum dosage of medicine that you need to take for it to be effective,” Hood said. “There’s also a limit to how much of the drug can be present in your system so that it doesn’t make you sick.”

As a result of these limitations, a person who needs frequent doses of a specific medicine is required to take a pill every day or visit a doctor for injections. Hood’s creation negates the need for either of these approaches...