cancer treatment tagged posts

Credit: Jian Yang, Yixue Su Artist’s conception of nanoparticle-carrying immune cells that target tumors and release drug-loaded nanoparticles for cancer treatment.

Penn State engineers have conjugating biodegradable polymer nanoparticles encapsulated with chosen cancer-fighting drugs into immune cells to create a smart, targeted system to attack cancers of specific types. “The traditional way to deliver drugs to tumors is to put the drug inside some type of nanoparticle and inject those particles into the bloodstream,” said Jian Yang, professor of biomedical engineering, Penn State. “Because the particles are so small, if they happen to reach the tumor site they have a chance of penetrating through the blood vessel wall because the vasculature of tumors is usually leaky.”

The odds of in...

This diagram describes how the device Dr. Hood helped to develop is implanted into a cancerous tumor. Credit: Lyle Hood/UTSA

Medicine diffusion capsule could locally treat multiple ailments and diseases over several weeks. This new device that could revolutionize the delivery of medicine. “The problem with most drug-delivery systems is that you have a specific minimum dosage of medicine that you need to take for it to be effective,” Hood said. “There’s also a limit to how much of the drug can be present in your system so that it doesn’t make you sick.”

As a result of these limitations, a person who needs frequent doses of a specific medicine is required to take a pill every day or visit a doctor for injections. Hood’s creation negates the need for either of these approaches...

Controlling Spatial Heat and Light Distribution by Using Photothermal Enhancing Auto-Regulated Liposomes (PEARLs).

Dr. Gang Zheng and a team of biomedical researchers have discovered a “smart” organic, biodegradable nanoparticle that uses heat and light in a controlled manner to potentially target and ablate tumours with greater precision. The proof-of-concept findings provide a viable approach to boosting the clinical utility of photo-thermal therapy in treating cancer, says Dr. Zheng, Senior Scientist at the Princess Margaret and Professor of Medical Biophysics at the University of Toronto.He talks about and demonstrates the research at https://youtu.be/EEN6Mz5iWBI.

In the lab, using phantom models, the “smart” nanoparticle the team has dubbed PEARLs – photo-thermal enhancing auto-regula...

ProAgio induces apoptosis by recruiting caspase 8, that plays an essential role in programmed cell death, to the cytoplasmic area of integrin v3

A protein designed Georgia State Uni researchers can effectively target a cell surface receptor linked to a number of diseases, showing potential as a therapeutic treatment for an array of illnesses, including cancer. ProAgio, which is created from a human protein, targets the cell surface receptor integrin v3 at a novel site that has not been targeted by other scientists. The researchers found ProAgio induces apoptosis of cells that express integrin v3. This integrin has been a focus for drug development because abnormal expression of v3 is linked to the development and progression of a number of diseases.

“This integrin pair, v3, is not expresse...