cancer vaccine tagged posts

Scientists develop a Cancer Vaccine to Simultaneously Kill and Prevent Brain Cancer

Scientists develop a cancer vaccine to simultaneously kill and prevent brain cancer
Scientists developed a bifunctional therapeutic strategy by transforming living tumor cells into a therapeutic. Shah’s team engineered living tumor cells using the gene editing tool CRISPR-Cas9 and repurposed them to release tumor cell killing agent. In addition, the engineered tumor cells were designed to express factors that would make them easy for the immune system to spot, tag and remember, priming the immune system for a long-term anti-tumor response. The team tested their repurposed CRISPR-enhanced and reverse-engineered therapeutic tumor cells (ThTC) in different mice strains including the one that bore bone marrow, liver and thymus cells derived from humans, mimicking the human immune microenvironment...
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New Vaccine Type Overcomes Cancerous Tumor Defenses

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Credit: Pixabay/CC0 Public Domain

A team of researchers affiliated with multiple institutions in the U.S. and one in Japan has developed a new type of vaccine that helps the immune system destroy cancerous tumors by overcoming their defense system. In their paper published in the journal Nature, the group describes the new vaccine and its effects in mouse and rhesus macaque models.

Until recently, the only tools available to doctors treating cancer patients have been chemotherapy, radiation treatment and surgery. More recently, medical researchers have been exploring vaccines in the fight against cancer—the development of a vaccine against HPV-related diseases, for example, has reduced the risks of cervical and other types of cancers...

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Breakthrough with cancer vaccine

TRI-based Mater researchers in partnership with The University of Queensland have developed a new cancer vaccine, which has shown promising signs in preclinical laboratory studies.

Scientists have developed a new cancer vaccine with the potential to activate the body’s immune system to fight a range of cancers, including leukaemia, breast cancer, lung cancer and pancreatic cancers.

Scientists are ready to trial a new cancer vaccine in humans following the successful outcome of their preclinical studies.

The new vaccine was developed by a Mater Research team based at The Translational Research Institute in collaboration with The University of Queensland.

Lead Researcher Associate Professor Kristen Radford says the vaccine has the potential to treat a variety of blood cancers ...

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Novel Cancer Vaccine Strategy Blocks Death of Tumor-specific Cytotoxic T cells

Drs. Esteban Celis and Hussein Sultan in the Georgia Cancer Center at Augusta University laboratory. Credit: Phil Jones, Senior Photographer, Augusta University

Drs. Esteban Celis and Hussein Sultan in the Georgia Cancer Center at Augusta University laboratory. Credit: Phil Jones, Senior Photographer, Augusta University

New research published in Cancer Immunology Research by Drs. Esteban Celis and Hussein Sultan of the Georgia Cancer Center at Augusta University could serve as the stepping-stone in constructing vaccines with a greater likelihood of finding and attacking tumors in the human body. According to Celis and Sultan, the key in this vaccine strategy is increasing the amount of time a cytokine called interleukin 2 (IL2) stays in the body. IL2 is a molecule in the immune system responsible for regulating the activity of some white blood cells known as killer T cells.

“After administering peptide-based vaccines in mouse models of cancer, we ...

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