cannabinoid receptors tagged posts

The brain’s white matter seen from the front as obtained by diffusion tensor imaging. Photograph: Institute of Psychiatry

Smoking high potency ‘skunk-like’ cannabis can damage a crucial part of the brain responsible for communication between the two brain hemispheres, according to a new study by scientists from King’s College London and Sapienza University of Rome.

Researchers have known for some time that long-term cannabis use increases the risk of psychosis, and recent evidence suggests that alterations in brain function and structure may be responsible for this greater vulnerability. However, this new research is the first to examine the effect of cannabis potency on brain structure.

Exploring the impact of cannabis potency is particularly important since today’s high potency ‘skunk-...

1st link between oxytocin and anandamide, which has been called the ‘bliss molecule’ for its role in activating cannabinoid receptors in brain cells to heighten motivation and happiness. Anandamide is among a class of naturally occurring chemicals in the body known as endocannabinoids that attach to the same brain cell receptors as does marijuana’s active ingredient, THC, with similar outcomes.

The researchers discovered that social contact increased production of anandamide in a brain structure called the nucleus accumbens, which triggered cannabinoid receptors there to reinforce the pleasure of socialization. When cannabinoid receptors were blocked, this reinforcement disappeared.

Piomelli’s team then looked for a possible connection between anandamide and oxytocin, which is well known ...