This is a schematic of how a “chimeric autoantibody receptor,” or CAAR, that displays fragments of the autoantigen Dsg3 helps fight an autoimmune disease called pemphigus vulgaris, a condition in which a patient’s own immune cells attack Dsg3, which normally adheres skin cells. Credit: Christoph T. Ellebrecht, MD, Perelman School of Medicine, University of Pennsylvania
Preclinical study shows that engineered T cells can selectively target the antibody-producing cells that cause autoimmune disease. The autoimmune disease the team studied is pemphigus vulgaris (PV), a condition in which a patient’s own immune cells attack a protein called desmoglein-3 (Dsg3) that normally adheres skin cells...
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