CAR-T cell therapy tagged posts

Scientists have engineered natural killer immune cells that not only kill head and neck tumour cells in mice but also reduce the immune-suppressing myeloid cells that allow tumours to evade the immune response, according to a new study in eLife.

The engineered cell therapy could be used as an alternative approach for treating cancer in patients for whom previous immunotherapy based on the activation of T cells has failed. These findings are reported by researchers at the U.S. National Institutes of Health (NIH) in Bethesda, Maryland.

In recent years, treatments called T-cell therapy or CAR-T cell therapy have been approved to treat blood cancers, and many others are now in development for othe...

A study by UCLA researchers is the first to demonstrate a technique for coaxing pluripotent stem cells – which can give rise to every cell type in the body and which can be grown indefinitely in the lab – into becoming mature T cells capable of killing tumor cells.

The technique uses structures called artificial thymic organoids, which work by mimicking the environment of the thymus, the organ in which T cells develop from blood stem cells.

T cells are cells of the immune system that fight infections, but also have the potential to eliminate cancer cells...

This March 2016 photo provided by the City of Hope hospital shows patient Richard Grady in Duarte, Calif. Suffering from a deadly brain cancer that had spread to his spine, a novel therapy, which helped his immune system attack his disease, shrank his tumors. Grady was the first person to get cells that were genetically modified to seek and kill cancer dripped through a tube into a space in the brain where spinal fluid is made, sending the cells down the path the cancer traveled to his spine. (City of Hope via AP)

A man with deadly brain cancer that had spread to his spine saw his tumors shrink and, for a time, completely vanish after a novel treatment to help his immune system attack his disease—another first in this promising field...