cardiac protein quality tagged posts

Aerobic exercise training rescues cardiac protein quality control and blunts endoplasmic reticulum stress in heart failure rats. ie AET blunted MI-induced ER stress by reducing protein levels of UPR markers, and accumulation of both misfolded and polyubiquinated proteins, which was associated with restored proteasome activity

Heart failure is a common endpoint for many cardiovascular diseases and is characterized by having reduced cardiac output that leads to dyspnea, exercise intolerance and later death. >20 million people worldwide have heart failure and this will get worse since the prevalence of heart failure will rise as the mean age of the population increases.

Despite heart failure seems to be a multifactorial syndrome, a common point observed by several studies was the accumulation...