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The top row depicts immature human heart muscle cells generated from stem cells. Their shape and fibre organisation is irregular. Upon Rbfox1 expression, the cells, as seen in the lower row, are more organised, closer to the shape and organisation of mature muscle cells in an adult heart. (Credit:[Huang J, Lee JZ, Rau CD, et al. Regulation of postnatal cardiomyocyte maturation by an RNA splicing regulator rbfox1. Circulation. 2023;148(16):1263-1266. doi: 10.1161/circulationaha.122.061602)
Researchers identify RBFox1 as a key intrinsic regulator of heart muscle cell maturation, overcoming a major limitation in cardiac regenerative therapy and disease modelling and demonstrating for the first time that RNA splicing control can significantly impact this process.
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