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This is a collection of SHERLOCK paper test strips. (Left) Unused paper strips. (Middle) Paper tests displaying a negative SHERLOCK readout. (Right) Paper tests displaying a positive SHERLOCK readout. Credit: Zhang lab, Broad Institute of MIT and Harvard

100-fold greater sensitivity, ability to detect multiple targets at once, and other improvements provide more power for detecting genetic signatures. The team that first unveiled the rapid, inexpensive, highly sensitive CRISPR-based diagnostic tool called SHERLOCK has greatly enhanced the tool’s power, and has developed a miniature paper test that allows results to be seen with the naked eye – without the need for expensive equipment.

The SHERLOCK team developed a simple paper strip to display test results for a single genetic signature, b...