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    CRISPR-based Strategy Edits Multiple Genes and could Treat Polygenic Diseases

    May 20, 2022, Categories  Biology/Biotechnology, Health/Medical

    Rice University engineers introduce DAP, a streamlined CRISPR-based technology that can perform many genome edits at once to address polygenic diseases. In experiments, DAP, for “drive-and-process,” enabled up to 31 edits with the base editor and three edits with the prime editor. Illustration by Qichen Yuan

    A genome-editing strategy developed at Rice University can correct dozens of errors at the same time with high precision and efficiency, a possible breakthrough for those who suffer from diseases caused by a combination of mutations.

    The “drive-and-process” array, DAP for short, also appears to be highly adept at avoiding off-target edits, errors that have plagued earlier gene-editing strategies.

    Engineer Xue Sherry Gao and graduate student and lead author Qichen Yuan of ...

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