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    Casein Kinase 1 delta (CK1δ) tagged posts

    Scientists Discover a Secret to Regulating our Body Clock, Offering New Approach to End Jet Lag

    October 9, 2024, Categories  Biology/Biotechnology, Health/Medical

    A peptide (shown in mesh) with attached phosphate tags (red and orange spheres) blocks the active site of CK1δ. Tagging the tail end of CK1δ, a process known as auto-phosphorylation, makes the protein less active, and with that less able to fine-tune the body’s internal clocks. // Credit: Jon Philpott, Rajesh Narasimamurthy and David Virshup

    Scientists from Duke-NUS Medical School and the University of California, Santa Cruz, have discovered the secret to regulating our internal clock. They identified that this regulator sits right at the tail end of Casein Kinase 1 delta (CK1δ), a protein which acts as a pacesetter for our internal biological clock or the natural 24-hour cycles that control sleep-wake patterns and other daily functions, known as circadian rhythm.

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