Highlights •CK2 is preferentially activated in white fat by norepinephrine and under obesity •CK2 inhibition in white fat activates thermogenesis in response to cAMP stimuli •CK2 inhibition increases UCP1-dependent energy expenditure in vivo •CK2 inhibition ameliorates diet-induced obesity and insulin resistance
Drugs that flip this switch rapidly reduced obesity and diabetes risk factors in mice fed a high fat diet. The results suggest that drugs capable of targeting similar molecular pathways in human fat cells could one day become major tools for fighting the growing worldwide epidemics of obesity and type 2 diabetes.
All mammals, including humans, have two types of fat with completely opposite functions: white, which stores energy and is linked with diabetes and obesity; and br...
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