CCNA2 tagged posts

Reactivating a fetal gene enables adult heart cells to regenerate after injury

Researchers reactivate a gene found to repair heart injury, offering hope for new therapies
Translational roadmap and mechanistic model of CCNA2 gene therapy for cardiac regeneration. Credit: npj Regenerative Medicine (2025). DOI: 10.1038/s41536-025-00438-7

Around the globe, heart disease remains one of the top causes of death. Once patients begin to suffer from serious heart problems, like heart attacks and heart failure, the heart muscles become damaged and are difficult to treat and repair. Although many therapies have been developed to treat symptoms, full recovery to a pre-disease state has been essentially impossible. This is due to a lack of regeneration ability in adult human heart cells. Studies using stem cells or progenitor cells for repair have demonstrated limited efficacy in clinical trials, thus far.

However, there may be new hope for these patients...

Read More