CD4+ T cells tagged posts

Certain immune cell subtypes drive lupus, study finds

New immune cell suspects in lupus
scRNA-seq reveals altered cellular composition of CD4+ T cells in SLE. Credit: Nature Immunology (2025). DOI: 10.1038/s41590-025-02297-2

Detailed mapping of CD4⁺ T cells from children with systemic lupus erythematosus (SLE) has revealed distinct immune cell subsets with likely roles in disease pathogenesis, according to a study led by Weill Cornell Medicine investigators. The findings are poised to redirect lupus research and open the door to more precise therapies that avoid broad immune suppression.

Published in Nature Immunology, the study used single-cell RNA sequencing to profile CD4⁺ T-cell subtypes from children with SLE and healthy controls...

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Kimchi acts as a ‘precision regulator’ for the immune system, 12-week clinical trial suggests

The world's first elucidation of the immunomodulatory effects of kimchi by the World Institute of Kimchi
Immunoregulatory mechanisms of kimchi. Credit: World Institute of Kimchi (WiKim)

Amid concerns about the simultaneous spread of multiple respiratory diseases, such as colds and influenza, with the change of seasons in current times, a clinical study has scientifically proven that kimchi, a traditional Korean fermented food, enhances the function of human immune cells and maintains the balance of the immune system.

The World Institute of Kimchi has reported the results of a single-cell genetic analysis that suggests that kimchi consumption has immunomodulatory effects, which include the suppression of excessive immune responses while simultaneously enhancing defense functions.

The results of the research are published in npj Science of Food.

This is the first study in the world...

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The IL-17 Protein plays a Key Role in Skin Aging

Immunofluorescence staining of IL-17(white) in aged mouse skin

A team of scientists from the Institute for Research in Biomedicine (IRB Barcelona) in collaboration with the National Center for Genomic Analysis (CNAG) has discovered that IL-17 protein plays a central role in skin ageing. The study, which was led by Dr. Guiomar Solanas, Dr. Salvador Aznar Benitah, both at IRB Barcelona, and Dr. Holger Heyn, at CNAG, highlights an IL-17-mediated ageing process to an Inflammatory state.

Skin ageing is characterised by a series of structural and functional changes that gradually contribute to the deterioration and fragility associated with age. Aged skin has a reduced capacity to regenerate, poor healing ability, and diminished barrier function.

Published in the journal Nature Aging, ...

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