Intrahepatic IFN-I signaling and responsive CD8+ T cells promote metabolic disease in mice and correlate to worsened NAFLD in humans.
A high-fat diet and obesity turn “hero” virus-fighting liver immune cells “rogue”, leading to insulin resistance, a condition that often results in type 2 diabetes, according to research published today in Science Immunology. Using cells from mice and human livers, Toronto General Hospital Research Institute researchers demonstrated for the first time how under specific conditions, such as obesity, liver CD8+ T cells, white blood cells in the control of viral infections, become highly activated and inflammatory, reprogramming themselves into disease-driving cells.
Scientists have been trying for many years to discover why the liver continues to pump out too ...
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