cDC1 tagged posts

Unravelling the Secret of a Critical Immune Cell for Cancer Immunity

Tissue captured under a microscope
DC-SCRIPT positive cells (red) activating an
immune response (blue T cells)
Credit: Wang Cao and Shengbo Zhang

WEHI researchers have discovered a key differentiation process that provides an essential immune function in helping to control cancer and infectious diseases.

The research, published in Science Immunology, is the first to show a new factor — DC-SCRIPT — is required for the function a particular type of dendritic cell — called cDC1 — that is essential in controlling the immune response to infection.

Led by WEHI Professor Stephen Nutt, Dr Michael Chopin and Mr Shengbo Zhang, it defines the role for a new regulatory protein in producing dendritic cells...

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