celiac disease tagged posts

New details on how certain gluten-derived molecules trigger leaky gut syndrome in affected individuals. Celiac disease is a chronic autoimmune condition that occurs in around one per cent of the world’s population. It is triggered by the consumption of gluten proteins from wheat, barley, rye and some oats. A gluten-free diet protects celiac patients from severe intestinal damage. Together with colleagues, chemist Dr Veronica Dodero from Bielefeld University was able to determine new details on how certain gluten-derived molecules trigger leaky gut syndrome in celiac disease.

The key finding of the study: a part...

Gluten is enemy No. 1 for those with celiac disease, and it’s hard to avoid. Episodes of this chronic autoimmune illness can be triggered by ingesting gluten, a key protein in wheat and some other grains. Researchers have been exploring how gut bacteria, especially Bifidobacteria, could be used as a treatment. Now, scientists publishing the results of laboratory experiments in ACS’ Journal of Agricultural and Food Chemistry report how specific types of Bifidobacteria work.

Humans have many types of bacteria living in their digestive systems, but those with celiac disease have altered levels of “beneficial” and “harmful” gut bacteria...

Only the part of the antibody (left) that binds to gluten is needed to create a product, which does not trigger an immune response. Credit: TU Wien

Meds alleviate or even completely eliminate the symptoms of celiac disease. In an industrial collaboration project, TU Wien has developed a medication that can alleviate or even completely eliminate the symptoms of celiac disease. It should be available as early as 2021. Celiac disease is a fairly common disease, affecting 1-2% of the European population. It is expressed as a hypersensitivity to gluten, a protein found in cereals such as wheat, barley or rye.

Although efforts are already being made to treat celiac disease, the proposed drugs have an effect on the immune system. Possible side effects must therefore be examined very carefully...

PRC1 (polycomb complex) maintains intestinal homeostasis by repressing the expression of ZICs, a family of transcription factors inactivating the β-catenin/TCF complex. Importantly, interfering with PRC1 activity completely inhibits the formation of Wnt-dependent tumors.

Researchers at the University of Tampere discovered a regulation mechanism governing the intestinal homeostasis. Disturbances in this mechanism are implicated in celiac disease and possibly also in colorectal cancer. The study provides new information on the pathogenesis of the differentiation defect of the epithelium in the small intestine in celiac disease.

In celiac disease, ingested dietary gluten causes intestinal mucosal damage with villus atrophy and crypt hyperplasia...