cell fate conversion tagged posts

Researchers reveal how Cells Rewrite their Fate

Researchers reveal how cells rewrite their fate
C/EBPαR35A interacts more strongly with PU.1 than unmated C/EBPα, shown here by an assay that scores the proximity of antibodies against the two proteins. Credit: Thomas Graf/Centre for Genomic Regulation

Researchers at the Centre for Genomic Regulation (CRG) in Barcelona and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association in Berlin have revealed how cells accelerate changes to their identity, a process known as cell fate conversion.

The study, published today in the journal eLife, has implications for cancer research as the disease often arises from errors in cell fate decisions. The study could eventually lead to new methods of accelerating or manipulating the molecular mechanisms involved in the formation of cancer.

Central to the study is C/EBPα...

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