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    cell’s integrated stress response (ISR) tagged posts

    ‘Spider-like’ Mitochondrial Structure Initiates Cell-wide Stress Response

    August 9, 2023, Categories  Biology/Biotechnology, Health/Medical

    “Spider-like” mitochondrial structure initiates cell-wide stress response
    A structural depiction of a mitochondrial protein structure that initiates a cell-wide stress response. Using electron microscopy, Scripps Research scientists showed that this protein complex is made up of eight identical fragments of a protein called DELE1 that bind together into a highly symmetrical cylindrical. Credit: Jie Yang, Scripps Research

    Often referred to as the “powerhouses of the cell,” mitochondria are well known for their role as energy suppliers, but these organelles are also critical for maintaining our overall health. Mitochondrial stress is associated with aging and age-related diseases, including neurodegeneration, but there has been a limited understanding of the cellular mechanisms behind this mitochondrial stress signaling...

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