cerebral cortex tagged posts

Brain changes in autism are comprehensive throughout the cerebral cortex rather than just particular areas thought to affect social behavior and language, according to a new UCLA-led study that significantly refines scientists’ understanding of how autism spectrum disorder (ASD) progresses at the molecular level.

The study, published today in Nature, represents a comprehensive effort to characterize ASD at the molecular level...

Different Sst interneurons, or type of nerve cell (colored red), in the outer shell, or cerebral cortex, of the mouse brain are shown. Credit: Courtesy of Science

Specialized nerve cells, somatostatin-expressing (Sst) interneurons, in the cerebral cortex – play a key role in controlling how information flows in the brain when it is awake and alert. In experiments in mice, they found that the activity of Sst interneurons changes when the animal goes from not moving its whiskers (in a resting state) to moving them (in an active state), a process known as whisking. Specifically, the team discovered that the cortex contains a diverse set of Sst interneuron subtypes that reach into different layers of the cortex. Some of the subtypes turn on while others turn off during whisking...

Reconstruction of a single cell with all imaged orientation-tuned synapses overlaid onto the orientation preference map; the cell is indicated by a triangle and its synapses are indicated by circles — both are colored by their preferred orientation. Credit: Max Planck Florida Institute for Neuroscience

Study points to an active role for dendrites in cortical processing. The cerebral cortex is the largest and most complex area of the brain, with 20 billion neurons and 60 trillion synapses-a neuronal network whose proper function is critical for sensory perception, motor control, and cognition. The part of the cerebral cortex devoted to vision has played a key role in elucidating fundamental principles that are used by cortical circuits to encode information.

As edges supply a wealth of info...

Plastic cells: A fast spiking interneuron in the cerebral cortex of the mouse. Image adapted from King’s College London press release.

It implies ‘hardware’ in our brain is tuneable and could have implications that go far beyond basic neuroscience – from informing education policy to developing new therapies for neurological disorders such as epilepsy.

Researchers from the MRC Centre for Developmental Neurobiology, led by Professor Oscar Marín have discovered some neurons in the cerebral cortex can adapt their properties in response to changes in network activity – such as those observed during learning of a motor task...