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    chemogenetics tagged posts

    Brain Regions that Relieve Effects of Chronic Stress in Mice Differ based on Sex

    December 18, 2024, Categories  Biology/Biotechnology, Health/Medical

    Schematic of cortical microcircuit showing connections among neurons and how activation of SST neurons leads to stress resilience
    New research finds sex-specific regions of the brain can relieve the detrimental effects of chronic stress in male and female mice. Left: Schematic showing a cortical microcircuit with three types of interneurons expressing somatostatin (SST), parvalbumin (PV) or vasointestinal peptide (VIP) and their distinct patterns of innervation of glutamatergic output neurons (PNs), with thin lines representing axons that send chemical signals and the thicker lines of PNs representing dendrites that receive information. There is selective innervation of the distal ends of PN dendrites by axons of SST neurons...
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