cholesterol tagged posts

Discovery could be a major step in developing therapies for cancer, controlling cholesterol. Columbia University scientists, in collaboration with researchers from Nimbus Therapeutics, have demystified a metabolic enzyme that could be the next major molecular target in cancer treatment.

The team has successfully determined the 3D structure of human ATP-citrate lyase (ACLY) – which plays a key role in cancer cell proliferation and other cellular processes – for the first time...

This is a fruit fly.
Credit: Carnegie Institution for Science

Body organs such as the intestine and ovaries undergo structural changes in response to dietary nutrients that can have lasting impacts on metabolism, as well as cancer susceptibility, according to Carnegie’s Rebecca Obniski, Matthew Sieber, and Allan Spradling. Their work, published by Developmental Cell, used fruit flies, which are currently the most-sensitive experimental system for such detecting diet-induced cellular changes that are likely to be similar in mammals.

There are 3 major types of cells in fruit fly (and mammalian) intestines: Stem cells, hormone-producing cells, and nutrient-handling cells...

Reductions in Atherogenic Lipids and Major Cardiovascular Events A Pooled Analysis of 10 ODYSSEY Trials Comparing Alirocumab With Control Credit: Imperial College London

Although previous studies have suggested lowering cholesterol levels may be associated with a lower risk of heart attack, recent evidence has questioned whether very low levels are beneficial.
In the latest study, led by scientists at Imperial College London, researchers analysed data from over 5,000 people taking part in cholesterol-lowering trials. These studies utilised a new therapy to reduce cholesterol to much lower levels than previously possible.

The scientists found that dropping cholesterol to the lowest level possible – to levels similar to those we were born with – reduced the risk of heart attack, stroke or fa...

Diet has already impacted guidelines in Canada and Europe. The research, published today in Nutrition, Metabolism and Cardiovascular Disease, was a secondary analysis of data collected for a 2011 study on the effect of the ‘portfolio diet’ on cholesterol. The portfolio diet lowered blood pressure by ~2%, when compared with another diet recommended to reduce hypertension.

The portfolio diet includes foods that are scientifically-proven to lower cholesterol including mixed nuts, soy protein, plant sterols (found in vegetable oils and leafy vegetables) and viscous fiber (found in oats, barley and eggplant). The comparison method, a dietary approach to stopping hypertension, or DASH diet, emphasizes fruit, vegetables and whole grains, reduced meat and dairy intake, and eliminating snack food.