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    chromatin tagged posts

    Powerful New Tool to Advance Genomics, Disease Research

    November 29, 2022, Categories  Biology/Biotechnology, Health/Medical

    Powerful new tool to advance genomics, disease research
    Image: Intrinsic cleavage biases affect single-cell ATAC-seq data analysis. Visualization of intrinsic cleavage bias effect in different cell clusters derived from scATAC-seq data for different biological samples and different experimental platforms: human hematopoietic cells (a–c), mixed human cell lines (d–f), mouse primitive gut tube (g–i), and 10× Single-Cell Multiome data for mouse embryonic brain (j–l), human peripheral blood mononuclear cells (PBMC) (m–o), and human lymph node (p–r). a, d, g, j, m, p UMAP visualization where cells are colored by cell type/labels/clusters. b, e, h, k, n, q Same UMAP visualization but cells are colored by cell bias score (CBS). c, f, i, l, o, r CBS distributions of cells from different cell types/batches/clusters...
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    Cancer: A Mutation that Breaks Gene Interplay in 3D

    January 29, 2019, Categories  Biology/Biotechnology, Health/Medical

    An illustration of chromatin contacts in the cell nucleus that activate transcription.
    Credit: Giovanni Ciriello (UNIL)

    Scientists have discovered how a mutated gene can affect the three-dimensional interactions of genes in the cell, leading to various forms of cancer. Inside the cell, DNA is tightly wrapped around proteins and packed in a complex, 3D structure that we call “chromatin.” Chromatin not only protects our genetic material from damage, but also organizes the entire genome by regulating the expression of genes in three dimensions, unwinding them to be presented to the cell’s gene-expression machinery and then winding them back in.

    Inside the 3D chromatin structure there are certain regions called “topologically associating domains” or TADs...

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