This image shows the binding profile of chromatin remodelers on 12,000 distinct genes. The researchers used bioinformatics tools to visualize a great number of genes, here aligned by their promoters and arranged according to their nucleosome distribution. Remodelers attached to nucleosomes (dark blue verticals lines) are present on each side of the gene promoter. The researchers identified two distinct nucleosomal architectures (represented by drawings at top and bottom). Researchers demonstrated that remodeler activity depends on this nucleosome organization: some are more specifically required for expression of genes at nucleosome-dense promoters (upper part), whereas others act preferentially on promoters with a low nucleosomal density (bottom part)...
Recent Comments