Circadian Clock controls Insulin tagged posts

Map of thousands of genes suggests new targets for diabetes. The scientists demonstrated knocking out clock genes led to obesity and type 2 diabetes, but they still had much to learn if they wanted to manipulate clock action to treat the conditions.”We knew that the pancreas didn’t work if we removed these clock genes, but we didn’t know how the genes were affecting the normal function of the pancreas,” said Dr. Joe Bass.

Clock genes are responsible for producing transcription factors, which help tell a cell how to function. In the new study Bass’s laboratory revealed thousands of genes in the pancreas that the clock’s transcription factors control in rhythm with the planet’s daily rotation from light to dark...