Highlights
•Transcriptional response to fasting is robustly rhythmic in liver and muscle
•Lack of food fails to sustain “free-running” conditions of peripheral circadian clocks
•Genes are temporally regulated by the clock and fasting-related transcription factors
•Rhythmic response to fasting is reversible by refeeding
Protects against aging-associated diseases. In a University of California, Irvine-led study, researchers found evidence that fasting affects circadian clocks in the liver and skeletal muscle, causing them to rewire their metabolism, which can ultimately lead to improved health and protection against aging-associated diseases. The study was published recently in Cell Reports.
The circadian clock operates within the body and its organs as intrinsic time-keepin...
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