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    circadian rhythm tagged posts

    Circadian Rhythm drives the Release of Important Immune Cells, study reveals

    June 19, 2024, Categories  Biology/Biotechnology, Health/Medical

    Circadian rhythm drives the release of important immune cells
    Credit: Cell Reports (2024). DOI: 10.1016/j.celrep.2024.114200

    The sites where our bodies come into contact with the outside world—via skin, the surface of the eye, inside the mouth, the lining of the intestine and the urinary tract, for example—are known as barrier tissues.

    Helping to defend those tissues are innate lymphoid cells, or ILCs, which when faced with a threat, stimulate proteins called cytokines that further activate the immune system and control the intestinal microbiome.

    These cells naturally diminish with aging or can be depleted by certain medical conditions.

    ILCs are made inside bone marrow and circulate in the blood. But how are they activated to mobilize and travel to their target sites to replenish the depleted pool of tissue ILCs?

    A Michigan Medi...

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    Bad timing is Depressing: Disrupting the Brain’s Internal Clock causes Depressive and anxiety-like behavior in mice

    November 29, 2016, Categories  Biology/Biotechnology, Health/Medical

    Bmal1/Clock complex activates transcription of genes containing E-box sequences in their promoters. Among these are Per1/2 and Cry1/2, which following dimerization can inhibit the activity of the Bmal1/Clock complex. Rev-Erb and Ror provide an additional stabilizing loop to fine-tune the expression of Bmal1. In addition to E-boxes, other clock regulatory elements (such as ROREs and D-boxes) are commonly found in the promoters of CCGs.

    Bmal1/Clock complex activates transcription of genes containing E-box sequences in their promoters. Among these are Per1/2 and Cry1/2, which following dimerization can inhibit the activity of the Bmal1/Clock complex. Rev-Erb and Ror provide an additional stabilizing loop to fine-tune the expression of Bmal1. In addition to E-boxes, other clock regulatory elements (such as ROREs and D-boxes) are commonly found in the promoters of CCGs.

    Disruptions of daily rhythms of the body’s master internal clock provide insight into the role of the brain’s internal time keeping system in the development of mood disorders, such as bipolar disorder and major depressive disorder MDD, which have been associated with disturbed daily (circadian) rhythms...

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    Powering up the Circadian Rhythm

    May 29, 2016, Categories  Biology/Biotechnology, Health/Medical

    Researchers led by the Salk Institute are the first to discover a protein that controls the strength of the body's circadian rhythms. A mouse liver with a "weak" circadian clock, caused by the targeted deletion of FBXW7 (right), has disrupted the lipid metabolism program and promoted lipid accumulation, compared to the normal liver (left). Credit: Salk Institute

    Researchers led by the Salk Institute are the first to discover a protein that controls the strength of the body’s circadian rhythms. A mouse liver with a “weak” circadian clock, caused by the targeted deletion of FBXW7 (right), has disrupted the lipid metabolism program and promoted lipid accumulation, compared to the normal liver (left). Credit: Salk Institute

    At noon, levels of genes and proteins throughout your body are drastically different than they are at midnight. Disruptions to this 24-hour cycle of physiological activity are why jet lag or a bad night’s sleep can alter your appetite and sleep patterns for days—and even contribute to conditions like heart disease, sleep disorders and cancers...

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    Rotation Speed may be bad news for Mars pioneers

    January 25, 2016, Categories  Astronomy/Space, Biology/Biotechnology, Health/Medical

    We really can’t have our astronauts getting loopy after just a few weeks on-planet, though, so researchers have been trying to find a way to re-program the body’s sleep cycle to the Martian standard. One method showing promise is the use of light-therapy — not just using bright light to knock the rhythm off kilter, but using the light’s specific wave-length as well. Extending the human sleep cycle might be as simple as exposing an astronaut to pale blue light at the end of their day. They hope to continue their research and determine which wavelengths have have an effect and what that is at different times of the day.

    We really can’t have our astronauts getting loopy after just a few weeks on-planet, though, so researchers have been trying to find a way to re-program the body’s sleep cycle to the Martian standard. One method showing promise is the use of light-therapy — not just using bright light to knock the rhythm off kilter, but using the light’s specific wave-length as well. Extending the human sleep cycle might be as simple as exposing an astronaut to pale blue light at the end of their day. They hope to continue their research and determine which wavelengths have have an effect and what that is at different times of the day. http://www.geek.com/science/mars-explorers-may-suffer-never-ending-jet-lag-1616740/

    New research reveals the importance of a circadian body clock that matches the r...

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