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Major Breakthrough in Understanding Alzheimer’s Disease

A human donor Alzheimer's disease brain tissue stained with an agent called 'congo-red', which allows for the visualization of amyloid-beta plaques (red) in the brain and surrounding blood vessels. Blue stains show the nuclei of the cells in the brain. Credit: Dr Matthew Campbell, 2015

A human donor Alzheimer’s disease brain tissue stained with an agent called ‘congo-red’, which allows for the visualization of amyloid-beta plaques (red) in the brain and surrounding blood vessels. Blue stains show the nuclei of the cells in the brain. Credit: Dr Matthew Campbell, 2015

Researchers believe that periodic clearance of a specific protein across the blood brain barrier could hold tremendous potential for new therapies. Scientists at Trinity College Dublin have shed light on a fundamental mechanism underlying the development of Alzheimer’s disease, which could lead to new forms of therapy for those living with the condition.

Alzheimer’s disease is characterized, in part, by the build-up of a small protein (‘amyloid-beta’) in the brains of patients...

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