colon cancer tagged posts

Antibiotic use (pills/capsules) is linked to a heightened risk of bowel (colon) cancer, but a lower risk of rectal cancer, and depends, to some extent, on the type and class of drug prescribed, suggests research published online in the journal Gut.

The findings suggest a pattern of risk that may be linked to differences in gut microbiome (bacteria) activity along the length of the bowel and reiterate the importance of judicious prescribing, say the researchers.

In 2010, patients around the world took an estimated 70 billion doses of antibiotics – equivalent to 10 doses each...

Activated ATF6 Induces Intestinal Dysbiosis and Innate Immune Response to
Promote Colorectal Tumorigenesis

The microbiota in the intestines fuels tumor growth. Scientists have made an unexpected discovery while investigating the triggering factors of colon cancer: Cell stress in combination with an altered microbiota in the colon drives tumor growth. Previously, it was assumed that this combination only contributes to inflammatory intestinal diseases.

“With our study we originally wanted to study the role of bacteria in the intestines in the development of intestinal inflammation,” explains Professor Dirk Haller from the Department of Nutrition and Immunology at the Weihenstephan Science Centre of the TUM...

This is a mouse colon from Cyp1a reporter mice after feeding with I3C.
Credit: Chris Schiering, Francis Crick Institute

Chemicals produced by vegetables such as kale, cabbage and broccoli could help to maintain a healthy gut and prevent colon cancer, a new study from the Francis Crick Institute shows. The research, published in Immunity, shows that mice fed on a diet rich in indole-3-carbinol – which is produced when we digest vegetables from the Brassica genus – were protected from gut inflammation and colon cancer.

While the health benefits of vegetables are well-established, many of the mechanisms behind them remain unknown...

Cans of soft drink. Cooling frozen and with water drops

Drinking artificially sweetened beverages is associated with a significantly lower risk of colon cancer recurrence and cancer death, a team of investigators led by a Yale Cancer Center scientist has found. The study was published today in PLOS ONE.

“Artificially sweetened drinks have a checkered reputation in the public because of purported health risks that have never really been documented,” said the study’s senior author, Charles S. Fuchs, M.D., director of Yale Cancer Center. “Our study clearly shows they help avoid cancer recurrence and death in patients who have been treated for advanced colon cancer, and that is an exciting finding.”

Fuchs and his team of researchers found that in the 1,018-patient analysis, those participants ...