colon cancer tagged posts

Increased apoptosis was induced by curcumin + silymarin combination treatment of DLD-1 colon cancer cells.

The combination of 2 plant compounds that have medicinal properties – curcumin and silymarin – holds promise in treating colon cancer, according Saint Louis University research published in the June 23 issue of the Journal of Cancer. Curcumin is the active ingredient in the spice turmeric, which is present in spicy curry dishes, and silymarin is a component of milk thistle, which has been used to treat liver disease.

The researchers and their students studied a line of colon cancer cells in a laboratory model. They found treating the cells initially with curcumin, then with silymarin was more effective in fighting cancer than treating the cells with either phytochemical alone.

“The co...

Dr. Turner’s lab team, most of who are shown here, were instrumental in the research relating to the health benefits of dried plums. (Texas A&M AgriLife Research photo)

A diet containing dried plums can positively affect microbiota, also referred to as gut bacteria, throughout the colon, helping reduce the risk of colon cancer, researchers report. According to the American Cancer Society, colon cancer is the third leading cause of cancer-related deaths in the U.S. when men and women are considered separately, and the second-leading cause when the figures are combined. During 2015, colon cancer is expected to cause about 49,700 deaths nationwide.

“Our research explored the potential cancer-protective properties of dried plums using a well-established rat model of colon cancer,” she sai...

Tom1 Modulates Binding of Tollip to Phosphatidylinositol 3-Phosphate via a Coupled Folding and Binding Mechanism •Tollip TBD is a disordered domain that partially folds when bound to Tom1 GAT •Tom1 GAT also directly binds to the Tollip C2 domain •Binding of Tom1 to Tollip inhibits binding of Tollip to PtdIns(3)P •Tollip TBD plays a major role in Tom1’s inhibitory function

It has important implications for Rx of allergies, heart disease, cancer types. The discovery explains how 2 particular proteins, Tollip and Tom1, work together to contribute to the turnover of cell-surface receptor proteins that trigger inflammation...

A novel test shows a difference in the Raman spectra of the blood plasma of people without colon cancer compared to those with precancerous or cancerous polyps. Credit: Haishan Zeng, BC Cancer Agency

It shows the simple fingerprint for cancerous growth and precancerous polyps. It may yield a cheaper and less invasive initial screening test for colon cancer that could complement colonoscopy, though further clinical trials will need to demonstrate the safety and effectiveness of the blood test before it is routinely used.

“This is a screening technology you can use on anybody,” said Haishan Zeng, BC Cancer Agency, who led the study...