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Circadian Disruption, Gut Microbiome Changes linked to Colorectal Cancer Progression

Circadian disruption, gut microbiome changes linked to colorectal cancer progression
Clock disruption and cancer alter microbial structure. Credit: Science Advances (2024). DOI: 10.1126/sciadv.ado1458

Research from the University of California, Irvine has revealed how disruption of the circadian clock, the body’s internal, 24-hour biological pacemaker, may accelerate the progression of colorectal cancer by affecting the gut microbiome and intestinal barrier function. This discovery offers new avenues for prevention and treatment strategies.

The study, published online today in the journal Science Advances, offers a more comprehensive understanding of how important changes occur in the function and composition of the gut microbiome when the circadian clock is disturbed in the presence of colorectal cancer.

“There is an alarming rise in early-onset colorectal can...

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