common variable immunodeficiency disease tagged posts

Genetic Overlapping in Multiple Autoimmune Diseases suggests Common Therapies/ Repurposing existing Drugs

 

Scientists who analyzed the genes involved in 10 autoimmune diseases that begin in childhood have discovered 22 genome-wide signals shared by 2 or more diseases. These shared gene sites may reveal potential new targets for treating many of these diseases, in some cases with existing drugs already available for non-autoimmune disorders. Autoimmune diseases, eg Type 1 diabetes, Crohn’s disease, and juvenile idiopathic arthritis, collectively affect 7 to 10% of the Western Hemisphere.

Meta-analysis was performed, incl a case-control study of 6,035 subjects with automimmune disease and 10,700 controls, all of European ancestry. Yun (Rose) Li, M.D./Ph.D...

Read More