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‘Resetting’ the Injured Brain Offers Clues for Concussion Treatment

About 85% of traumatic brain injuries are similar to the type of concussion examined in this study, involving dispersed impact to the head.
Illustration: Getty Images

In mice, ‘turning over’ cells reverses cognitive, behavior problems. New research in mice raises the prospects for development of post-concussion therapies that could ward off cognitive decline and depression, two common conditions among people who have experienced a moderate traumatic brain injury.

The study in mice clarified the role of specific immune cells in the brain that contribute to chronic inflammation. Using a technique called forced cell turnover, researchers eliminated these cells in the injured brains of mice for a week and then let them repopulate for two weeks.

“It’s almost like hitting the reset butt...

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