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Dopamine Controls Movement, not just Rewards

Microscopy image of a dopamine neuron subtype that displays activity correlated to locomotion but no response to rewards. Image by Maite Azcorra and Zachary Gaertner

New study finds dopamine neurons are more diverse than previously thought. Although there is a long-standing, common assumption that most – if not all – dopamine neurons solely respond to rewards or reward-predicting cues, researchers instead discovered that one genetic subtype fires when the body moves and does not respond to rewards at all. The discovery could help explain why loss of dopamine neurons leads to Parkinson’s disease.

In a new Northwestern University-led study, researchers identified and recorded from three genetic subtypes of dopamine neurons in the midbrain region of a mouse model.

Although there is ...

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