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    New Antiviral Drug Inhibits epidemic SARS, MERS and animal Coronaviruses

    June 29, 2017, Categories  Biology/Biotechnology, Health/Medical

    GS-5734 is effective against a diverse array of human and zoonotic CoV in HAE. (A) Neighbor-joining trees created with representatives from all four CoV genogroups showing the genetic similarity of CoV nsp12 (RdRp) and CoV spike glycoprotein, which mediates host tropism and entry into cells. Text color of the virus strain label corresponds to virus host species on the left. The heatmap adjacent to each neighbor-joining tree depicts percent amino acid identity (% A.A. identity) against SARS-CoV or MERS-CoV.

    GS-5734 is effective against a diverse array of human and zoonotic CoV in HAE.
    (A) Neighbor-joining trees created with representatives from all four CoV genogroups showing the genetic similarity of CoV nsp12 (RdRp) and CoV spike glycoprotein, which mediates host tropism and entry into cells. Text color of the virus strain label corresponds to virus host species on the left. The heatmap adjacent to each neighbor-joining tree depicts percent amino acid identity (% A.A. identity) against SARS-CoV or MERS-CoV.

    A new antiviral drug candidate inhibits a broad range of coronaviruses, including the SARS and MERS coronaviruses. The findings support further development of the drug candidate for treating and preventing current coronavirus infections and potential future epidemic outbreaks.

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