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    COVID-19 tagged posts

    Scientists discover Key Element of Strong Antibody response to COVID-19

    July 16, 2020, Categories  Biology/Biotechnology, Health/Medical

    Many anti-SARS-CoV-2 antibodies are produced by a common antibody gene. X-ray crystallography revealed how specific features of these antibodies (two of which are depicted here in yellow and orange, attached to the virus) enable potent recognition of the virus’s spike protein. Graphic by Meng Yuan, Hejun Liu and Nicholas Wu in the Wilson lab.

    The findings support many vaccine strategies being used to tackle the new coronavirus. A team led by scientists at Scripps Research has discovered a common molecular feature found in many of the human antibodies that neutralize SARS-CoV-2, the coronavirus that causes COVID-19.

    The scientists, whose study appears July 13 in Science, reviewed data on nearly 300 anti-SARS-CoV-2 antibodies that their labs and others have found in convalescent COVID...

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    Hamsters develop protective Immunity to COVID-19 and are Protected by Convalescent Sera

    June 24, 2020, Categories  Biology/Biotechnology, Health/Medical

    Three x-rays of hamster lungs
    Images of the lungs of hamsters before and after infection with SARS-CoV-2, from CT scans at UW Veterinary Care at the School of Veterinary Medicine. In blue are the trachea and bronchi. In red is a region of gas in the cavity just outside the lungs, indicating severe lung damage in the affected animal. The opaque clouding is similar to the “ground glass” appearance in the lungs of some human patients sick with COVID-19. Signs of severe disease in the lungs of hamsters became apparent within eight days of infection and began to improve by 10 days. The effects lingered for longer, as evident on the scan taken 16 days after initial infection. COURTESY OF YOSHIHIRO KAWAOKA

    In an animal model for COVID-19 that shares important features of human disease, scientists at the University...

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    Super-potent Human Antibodies protect against COVID-19 in Animal Tests

    June 16, 2020, Categories  Biology/Biotechnology, Health/Medical

    A human antibody (blue) attaches to the receptor binding domain (red) on the SARS-CoV-2 virus. (Model courtesy of the Burton lab.)

    Scientists isolate powerful coronavirus-neutralizing antibodies from COVID-19 patients and successfully test in animals. A team led by Scripps Research has discovered antibodies in the blood of recovered COVID-19 patients that provide powerful protection against SARS-CoV-2, the coronavirus that causes the disease, when tested in animals and human cell cultures.

    The research, published today in Science, offers a paradigm of swift reaction to an emergent and deadly viral pandemic, and sets the stage for clinical trials and additional tests of the antibodies, which are now being produced as potential treatments and preventives for COVID-19.

    “The discover...

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    Imaging reveals Bowel Abnormalities in Patients with COVID-19

    May 12, 2020, Categories  Biology/Biotechnology, Health/Medical

    Coronal CT of the abdomen and pelvis with IV contrast in a 47-year-old man with abdominal tenderness demonstrates typical findings of mesenteric ischemia and infarction, including pneumatosis intestinalis (arrow) and non-enhancing bowel (*). Frank discontinuity of a thickened loop of small bowel in the pelvis (thin arrow) is in keeping with perforation.

    Patients with COVID-19 can have bowel abnormalities, including ischemia, according to a new study published recently in the journal Radiology.

    Several studies have evaluated the chest imaging findings in COVID-19, which helped improve understanding of how the disease affects the lungs. More recently, reports have documented that gastrointestinal symptoms, liver injury, and vascular findings are common in these patients...

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