COVID-19 tagged posts

Trial Drug can significantly Block Early stages of COVID-19 in engineered human tissues

In cell cultures analyzed in the current study, hrsACE2 inhibited the coronavirus load by a factor of 1,000-5,000. Credit: IMBA/Tibor Kulcsar

An international team led by University of British Columbia researcher Dr. Josef Penninger has found a trial drug that effectively blocks the cellular door SARS-CoV-2 uses to infect its hosts.

The findings, published today in Cell, hold promise as a treatment capable of stopping early infection of the novel coronavirus that, as of April 2, has affected more than 981,000 people and claimed the lives of 50,000 people worldwide.

The study provides new insights into key aspects of SARS-CoV-2, the virus that causes COVID-19, and its interactions on a cellular level, as well as how the virus can infect blood vessels and kidneys.

“We are hopefu...

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Reusable Respirators may be a suitable Alternative to Disposable Respirators

A reusable respirator on a table
credit: NIOSH / CDC
A reusable respirator.

Researchers have found that reusable respirators may be a suitable alternative to disposable N95 respirators currently in high demand. Shortages of respiratory protective devices for healthcare personnel are major concerns during the COVID-19 pandemic. A team of researchers at Baylor College of Medicine, Emory University, the University of Texas Health Science Center at Houston and the National Institute for Occupational Safety and Health Centers at the Centers for Disease Control and Prevention have found that reusable respirators may be a suitable alternative to disposable N95 respirators currently in high demand. The study appears in the journal JAMA.

“Training and fit testing healthcare providers on respirators can be time consuming, a...

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COVID-19: Stopgap Measure to Treat Respiratory Distress

Researchers from MIT and the University of Colorado at Denver propose using a protein called tissue plasminogen activator, whose structure is shown here, to treat Covid-19 patients in acute respiratory distress.
Image: Wikimedia, MedicineFTWq; edited by MIT News

Researchers at MIT and the University of Colorado at Denver have proposed a stopgap measure that they believe could help Covid-19 patients who are in acute respiratory distress. By repurposing a drug that is now used to treat blood clots, they believe they could help people in cases where a ventilator is not helping, or if a ventilator is not available.

Three hospitals in Massachusetts and Colorado are developing plans to test this approach in severely ill Covid-19 patients...

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Coronavirus Patients, Doctors seem to be temporarily Losing their sense of Taste and Smell — here’s why

Healthcare workers wait for people to arrive at a COVID-19 mobile testing site in Florida. New reports from the UK show that both doctors and patients with exposure to the coronavirus are temporarily losing their sense of smell and taste. (Photo: Paul Hennessy/NurPhoto via Getty Images)

As COVID-19 continues to spread, now topping 370,000 cases worldwide, mentions of a previously unknown symptom of COVID-19 — loss of smell — are gaining traction. “Haven’t been able to smell anything for the last 4 days,” tweeted Rudy Gobert, a player of the Utah Jazz who was the first NBA player to test positive for the coronavirus 11 days ago. “Anyone experiencing the same thing?

According to a paper published Friday by Claire Hopkins, PhD, a professor of rhinology at King’s College Londo...

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